The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more subtle polymorphic variations influencing the pop...

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Bibliographic Details
Main Authors: Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Metabolism
Subjects:
Melanocortin
Hypothalamus
Obesity
Genetics
Pharmacology
Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000466

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http://www.sciencedirect.com/science/article/pii/S2212877821000466

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