Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs.

Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs.

BACKGROUND: Mechanical ventilation (MV) with high tidal volumes (V(T)) can cause or aggravate lung damage, so-called ventilator induced lung injury (VILI). The relationship between specific mechanical events in the lung and the cellular responses that result in VILI remains incomplete. Since activat...

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Bibliographic Details
Main Authors: Jesús Villar, Nuria E Cabrera, Francisco Valladares, Milena Casula, Carlos Flores, Lluís Blanch, María Elisa Quilez, Norberto Santana-Rodríguez, Robert M Kacmarek, Arthur S Slutsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3174135?pdf=render

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http://europepmc.org/articles/PMC3174135?pdf=render

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