Though active on RINm5F insulinoma cells and cultured pancreatic islets, recombinant IL-22 fails to modulate cytotoxicity and disease in a protocol of streptozotocin-induced experimental diabetes.

Though active on RINm5F insulinoma cells and cultured pancreatic islets, recombinant IL-22 fails to modulate cytotoxicity and disease in a protocol of streptozotocin-induced experimental diabetes.

Interleukin (IL)-22 is a cytokine displaying tissue protective and pro-regenerative functions in various preclinical disease models. Anti-bacterial, pro-proliferative, and anti-apoptotic properties mediated by activation of the transcription factor signal transducer and activator of transcription (S...

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Bibliographic Details
Main Authors: Anika eBerner, Malte eBachmann, Christine eBender, Josef ePfeilschifter, Urs eChristen, Heiko eMühl
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Pharmacology
Subjects:
STAT3 Transcription Factor
IL-22
Tissue Regeneration
tissue protection
RINm5F cells
Streptozotocin-diabetes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00317/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00317/full

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