Investigation of isoniazid and ethionamide cross-resistance by whole genome sequencing and association with poor treatment outcomes of multidrug-resistant tuberculosis patients in South Africa

Investigation of isoniazid and ethionamide cross-resistance by whole genome sequencing and association with poor treatment outcomes of multidrug-resistant tuberculosis patients in South Africa

Objective/background: Ethionamide (ETH) and isoniazid (INH) are part of the backbone regimen used for the treatment of multidrug-resistant tuberculosis (MDR-TB). Both ETH and INH are structurally similar and are activated by ethA and katG gene products. Resistance to INH among MDR-TB patients may ca...

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Bibliographic Details
Main Authors: L Malinga, J Brand, C Jansen van Rensburg, G Cassell, M van der Walt
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:International Journal of Mycobacteriology
Subjects:
Eastern Cape
Ethionamide
Isoniazid
KwaZulu-Natal
Treatment failure
Whole genome sequencing
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2016;volume=5;issue=5;spage=36;epage=37;aulast=Malinga

Internet

http://www.ijmyco.org/article.asp?issn=2212-5531;year=2016;volume=5;issue=5;spage=36;epage=37;aulast=Malinga

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