Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling

Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling

Nuclear factor kappa B (NF-κB) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal disorders. Several plant-derived sesquiterpene lactones can inhibit the activation of NF-κB. Parthenolide (PTL) is an abundant sesquiterpene...

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Bibliographic Details
Main Authors: Jin-Ho Park, Young-Hoon Kang, Sun-Chul Hwang, Se Heang Oh, June-Ho Byun
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
parthenolide
TNF-α
periosteum-derived cells
osteoblastic differentiation
JNK signaling
Online Access:https://www.mdpi.com/1422-0067/21/15/5433

Internet

https://www.mdpi.com/1422-0067/21/15/5433

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