Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9

Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9

Abstract Background Congenital hyper-homocysteinemia (HHcy) is caused by a defective cystathionine β-synthase (CBS) gene, and is frequently associated with dyslipdemia. The aim of this study was to further elucidate the effect of mutated CBS gene on circulating lipids using a rabbit model harboring...

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Bibliographic Details
Main Authors: Ting Zhang, Rui Lu, Yibing Chen, Yuguo Yuan, Shaozheng Song, Kunning Yan, Yiwen Zha, Wenwen Zhuang, Yong Cheng, Jingyan Liang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Lipids in Health and Disease
Subjects:
Cystathionine β-synthase
Hyperhomocysteinemia
Dyslipidemia
Rabbits
CRISPR/Cas9
G307S mutation
Online Access:http://link.springer.com/article/10.1186/s12944-020-01394-5

Internet

http://link.springer.com/article/10.1186/s12944-020-01394-5

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