Genes Implicated in Familial Parkinson’s Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage

Genes Implicated in Familial Parkinson’s Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage

The mechanism of nigral dopaminergic neuronal degeneration in Parkinson’s disease (PD) is unknown. One of the pathological characteristics of the disease is the deposition of α-synuclein (α-syn) that occurs in the brain from both familial and sporadic PD patients. This paper constitutes a narrative...

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Bibliographic Details
Main Authors: Rafael Franco, Rafael Rivas-Santisteban, Gemma Navarro, Annalisa Pinna, Irene Reyes-Resina
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
vesicular transport
mitophagy
Lewy bodies
synuclein aggregation
familial Parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/22/9/4643

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https://www.mdpi.com/1422-0067/22/9/4643

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