The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses

The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses

Influenza A viruses (IAV) comprise some of the most common infectious pathogens in humans, and they cause significant mortality and morbidity in immunocompromised people as well as children and the elderly. After screening an FDA-approved drug library containing 1280 compounds by cytopathic effect (...

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Bibliographic Details
Main Authors: Wei Xu, Shuai Xia, Jing Pu, Qian Wang, Peiyu Li, Lu Lu, Shibo Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
antihistamine
carbinoxamine
chlorpheniramine
influenza virus
viral entry
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02643/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02643/full

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