Genome wide association and linkage analyses identified three loci -- 4q25, 17q23.2 and 10q11.21 -- associated with variation in leukocyte telomere length: The Long Life Family Study

Genome wide association and linkage analyses identified three loci -- 4q25, 17q23.2 and 10q11.21 -- associated with variation in leukocyte telomere length: The Long Life Family Study

Leukocyte telomere length is believed to measure cellular aging in humans, and short leukocyte telomere length is associated with increased risks of late onset diseases, including cardiovascular disease, dementia, etc. Many studies have shown that leukocyte telomere length is a heritable trait, and...

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Bibliographic Details
Main Authors: Joseph H Lee, Rong eCheng, Lawrence S Honig, Mary eFeitosa, Candace eKammerer, Min Suk Kang, Nicole eSchupf, Jiuan eLin, Jason L Sanders, Harold T Bae, Todd eDruley, Thomas T Perls, Kaare eChristensen, Michael eProvince, Richard eMayeux
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Genetics
Subjects:
Aging
genome wide association study
leukocyte telomere length
familial longevity
family-based study
novel genes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00310/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00310/full

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