Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

The aim of this study was to design, optimize, and develop metronidazole (Met) loaded nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk assessment methodology. A fractional factorial design was used by selecting five independent variables viz., chitosan concentration, t...

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Bibliographic Details
Main Authors: Nagaraja Sreeharsha, Kuldeep Rajpoot, Muktika Tekade, Dnyaneshwar Kalyane, Anroop B. Nair, Katharigatta N. Venugopala, Rakesh K. Tekade
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
metronidazole
nanoparticles
chitosan
QbD
Eudragit S100
colon-specific delivery
Online Access:https://www.mdpi.com/1999-4923/12/10/920

Internet

https://www.mdpi.com/1999-4923/12/10/920

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