Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice

Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice

Romosozumab, a humanized monoclonal antibody specific for sclerostin (SOST), has been approved for treatment of postmenopausal women with osteoporosis at a high risk for fracture. Previous work in sclerostin global knockout (<i>Sost</i><sup>−/−</sup>) mice indicated alteratio...

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Bibliographic Details
Main Authors: Cristine Donham, Betsabel Chicana, Alexander G. Robling, Asmaa Mohamed, Sonny Elizaldi, Michael Chi, Brian Freeman, Alberto Millan, Deepa K. Murugesh, Nicholas R. Hum, Aimy Sebastian, Gabriela G. Loots, Jennifer O. Manilay
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
osteoimmunology
osteopetrosis
genetic animal models
aging
Online Access:https://www.mdpi.com/1422-0067/22/17/9111

Internet

https://www.mdpi.com/1422-0067/22/17/9111

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