HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs

HSP90 inhibition overcomes EGFR amplification‐induced resistance to third‐generation EGFR‐TKIs

Abstract Background Patients with non‐small cell lung cancer (NSCLC) harboring activating EGFR mutations are sensitive to epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs) but inevitably develop resistance to the inhibitors mostly through acquisition of the secondary T790M muta...

Full description

Bibliographic Details
Main Authors: Sho Watanabe, Yasushi Goto, Hiroyuki Yasuda, Takashi Kohno, Noriko Motoi, Yuichiro Ohe, Hiroyoshi Nishikawa, Susumu S. Kobayashi, Kazuyoshi Kuwano, Yosuke Togashi
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Thoracic Cancer
Subjects:
acquired resistance
and heat shock protein 90
epidermal growth factor receptor
epidermal growth factor receptor amplification
epidermal growth factor receptor‐tyrosine kinase inhibitor
Online Access:https://doi.org/10.1111/1759-7714.13839

Internet

https://doi.org/10.1111/1759-7714.13839

Similar Items