Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma.

Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma.

High-risk neuroblastoma is associated with an overall survival rate of 30-50%. Neuroblastoma-expressed cell adhesion receptors of the integrin family impact cell adhesion, migration, proliferation and survival. Integrin α4 is essential for neural crest cell motility during development, is highly exp...

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Bibliographic Details
Main Authors: Shanique A Young, Katelyn E McCabe, Alena Bartakova, Joe Delaney, Donald P Pizzo, Robert O Newbury, Judith A Varner, David D Schlaepfer, Dwayne G Stupack
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4431816?pdf=render

Internet

http://europepmc.org/articles/PMC4431816?pdf=render

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