Functional characterization of FLT3 receptor signaling deregulation in acute myeloid leukemia by single cell network profiling (SCNP).

Functional characterization of FLT3 receptor signaling deregulation in acute myeloid leukemia by single cell network profiling (SCNP).

BACKGROUND: Molecular characterization of the FMS-like tyrosine kinase 3 receptor (FLT3) in cytogenetically normal acute myeloid leukemia (AML) has recently been incorporated into clinical guidelines based on correlations between FLT3 internal tandem duplications (FLT3-ITD) and decreased disease-fre...

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Bibliographic Details
Main Authors: David B Rosen, Mark D Minden, Steven M Kornblau, Aileen Cohen, Urte Gayko, Santosh Putta, John Woronicz, Erik Evensen, Wendy J Fantl, Alessandra Cesano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2965086?pdf=render

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http://europepmc.org/articles/PMC2965086?pdf=render

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