Autologous hematopoietic stem cell transplantation in systemic sclerosis induces long-lasting changes in B cell homeostasis toward an anti-inflammatory B cell cytokine pattern

Autologous hematopoietic stem cell transplantation in systemic sclerosis induces long-lasting changes in B cell homeostasis toward an anti-inflammatory B cell cytokine pattern

Abstract Background Autologous hematopoietic stem cell transplantation (aHSCT) is performed in patients with aggressive forms of systemic sclerosis (SSc). The profile of B cell reconstitution after aHSCT is not fully understood. The aim of this study was to investigate changes of B cell subsets and...

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Bibliographic Details
Main Authors: Michael Gernert, Hans-Peter Tony, Eva Christina Schwaneck, Ottar Gadeholt, Marc Schmalzing
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
B cells
Memory B cells
naïve B cells
Autologous hematopoietic stem cell transplantation
Interleukin-10
Online Access:http://link.springer.com/article/10.1186/s13075-019-1889-8

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http://link.springer.com/article/10.1186/s13075-019-1889-8

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