Multimodal image-guided surgery of HER2-positive breast cancer using [111In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model

Multimodal image-guided surgery of HER2-positive breast cancer using [111In]In-DTPA-trastuzumab-IRDye800CW in an orthotopic breast tumor model

Abstract Background Combining modalities using dual-labeled antibodies may allow preoperative and intraoperative tumor localization and could be used in image-guided surgery to improve complete tumor resection. Trastuzumab is a monoclonal antibody against the human epidermal growth factor-2 (HER2) r...

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Bibliographic Details
Main Authors: Marion M. Deken, Desirée L. Bos, Willemieke S. F. J. Tummers, Taryn L. March, Cornelis J. H. van de Velde, Mark Rijpkema, Alexander L. Vahrmeijer
Format: Article
Language:English
Published: SpringerOpen 2019-11-01
Series:EJNMMI Research
Subjects:
Multimodal imaging
HER2-positive breast cancer
[111In]In-DTPA-trastuzumab-IRDye800CW
Fluorescence
Image-guided surgery
Online Access:http://link.springer.com/article/10.1186/s13550-019-0564-z

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http://link.springer.com/article/10.1186/s13550-019-0564-z

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