Virus-Like Particle Mediated CRISPR/Cas9 Delivery for Efficient and Safe Genome Editing

The discovery of designer nucleases has made genome editing much more efficient than before. The designer nucleases have been widely used for mechanistic studies, animal model generation and gene therapy development. However, potential off-targets and host immune responses are issues still need to b...

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Bibliographic Details
Main Authors: Pin Lyu, Luxi Wang, Baisong Lu
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Life
Subjects:
RNA
Online Access:https://www.mdpi.com/2075-1729/10/12/366