Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy

Protein kinases and phosphatases signal by phosphorylation and dephosphorylation to precisely control the activities of their individual and common substrates for a coordinated cellular outcome. In many situations, a kinase/phosphatase complex signals dynamically in time and space through their reci...

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Bibliographic Details
Main Authors: Xiao-Mei Qi, Fang Wang, Matthew Mortensen, Ryan Wertz, Guan Chen
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383518301436