Ppp6c deficiency accelerates K‐rasG12D‐induced tongue carcinogenesis

Ppp6c deficiency accelerates K‐rasG12D‐induced tongue carcinogenesis

Abstract Background Effective treatments for cancer harboring mutant RAS are lacking. In Drosophila, it was reported that PP6 suppresses tumorigenicity of mutant RAS. However, the information how PP6 regulates oncogenic RAS in mammals is limited. Methods We examined the effects of PP6 gene (Ppp6c) d...

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Bibliographic Details
Main Authors: Kazuhiro Kishimoto, Kosuke Kanazawa, Miyuki Nomura, Takuji Tanaka, Taeko Shigemoto‐Kuroda, Katsuya Fukui, Koh Miura, Koreyuki Kurosawa, Masaaki Kawai, Hiroyuki Kato, Keiko Terasaki, Yoshimi Sakamoto, Yoji Yamashita, Ikuro Sato, Nobuhiro Tanuma, Keiichi Tamai, Issay Kitabayashi, Kazuto Matsuura, Toshio Watanabe, Jun Yasuda, Hiroyuki Tsuji, Hiroshi Shima
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Cancer Medicine
Subjects:
chemokines
head and neck squamous cell carcinoma
K‐ras
protein phosphatase 6
Trp53
Online Access:https://doi.org/10.1002/cam4.3962

Internet

https://doi.org/10.1002/cam4.3962

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