Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells

Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells

Abstract Background Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide adenine dinucleotide (NAD) levels are crucial for liver function. The saturated fatty acid palmitate and the unsaturated fatty acid oleate are the main free fatty acids in adipose tissue and human diet. We asked how...

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Bibliographic Details
Main Authors: Melanie Penke, Susanne Schuster, Theresa Gorski, Rolf Gebhardt, Wieland Kiess, Antje Garten
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Lipids in Health and Disease
Subjects:
NAMPT
NAD
NMN
FK866
Steatosis
Liver
Online Access:http://link.springer.com/article/10.1186/s12944-017-0583-6

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http://link.springer.com/article/10.1186/s12944-017-0583-6

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