Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition

Summary: Exosomes can serve as delivery vehicles for advanced therapeutics. The components necessary and sufficient to support exosomal delivery have not been established. Here we connect biochemical composition and activity of exosomes to optimize exosome-mediated delivery of small interfering RNAs...

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Bibliographic Details
Main Authors: Reka Agnes Haraszti, Rachael Miller, Michelle L. Dubuke, Hannah E. Rockwell, Andrew H. Coles, Ellen Sapp, Marie-Cecile Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John Leszyk, Julia F. Alterman, Bruno M.D.C. Godinho, Matthew R. Hassler, Justice McDaniel, Niven R. Narain, Rachel Wollacott, Yang Wang, Scott A. Shaffer, Michael A. Kiebish, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900421930166X

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http://www.sciencedirect.com/science/article/pii/S258900421930166X

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