Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome

Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome

The proteasome is a validated target in drug discovery for diseases associated with unusual proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24, inhibit the peptidase activity of the 26S proteasome. The objective of this study was to investigate interaction of these...

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Bibliographic Details
Main Authors: Geeta Rao, Gregory Nkepang, Jian Xu, Hooman Yari, Hailey Houson, Chengwen Teng, Vibhudutta Awasthi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Chemistry
Subjects:
proteasome
CLEFMA
EF24
RPN13
proteasome inhibitors
dienone
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00392/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00392/full

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