Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.

Multiple cysteine proteases of malaria parasites are required for maintenance of parasite metabolic homeostasis and egress from the host erythrocyte. In Plasmodium falciparum these proteases appear to mediate the processing of hemoglobin and aspartic proteases (plasmepsins) in the acidic food vacuol...

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Main Authors: Byoung-Kuk Na, Young-An Bae, Young-Gun Zo, Youngchool Choe, Seon-Hee Kim, Prashant V Desai, Mitchell A Avery, Charles S Craik, Tong-Soo Kim, Philip J Rosenthal, Yoon Kong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC2953480?pdf=render