TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression

TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression

Abstract Background The major limitation of organ transplantation is the shortage of available organs. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection is a major hurdle for the successful survival of pig xenografts in primate recipients. Cytokines pl...

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Bibliographic Details
Main Authors: Hanchao Gao, Mengtao Cao, Pengfei Chen, David K. C. Cooper, Yanli Zhao, Ling Wei, Jia Xu, Zhiming Cai, Changchun Zeng, Shaodong Luan, Lisha Mou
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cell Communication and Signaling
Subjects:
Antibody-mediated complement-dependent cytotoxicity
P38
Porcine endothelial cells
TNF-α
Xenotransplantation
Online Access:http://link.springer.com/article/10.1186/s12964-019-0386-7

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http://link.springer.com/article/10.1186/s12964-019-0386-7

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