Evaluation of the Hippocampal Normal Tissue Complication Model in a Prospective Cohort of Low Grade Glioma Patients—An Analysis Within the EORTC 22033 Clinical Trial

Evaluation of the Hippocampal Normal Tissue Complication Model in a Prospective Cohort of Low Grade Glioma Patients—An Analysis Within the EORTC 22033 Clinical Trial

Purpose: To evaluate the performance of the hippocampal normal tissue complication model that relates dose to the bilateral hippocampus to memory impairment at 18 months post-treatment in a population of low-grade glioma (LGG) patients.Methods: LGG patients treated within the radiotherapy-only arm o...

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Bibliographic Details
Main Authors: Jaap Jaspers, Alejandra Mèndez Romero, Mischa S. Hoogeman, Martin van den Bent, Ruud G. J. Wiggenraad, Martin J. B. Taphoorn, Danielle B. P. Eekers, Frank J. Lagerwaard, Anna Maria Lucas Calduch, Brigitta G. Baumert, Martin Klein
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
NTCP (normal tissue complication probability) model
low grade glioma (LGG)
model verification and validation
neurocognition
memory
late effect of cancer treatment
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00991/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00991/full

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