A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

Peterle et al. show that a subtilisin like serine protease secreted from gut microbiota Bacillus subtilis cleaves the wild-type human transthyretin (hTTR) to generate an amyloidogenic peptide. High propensity of the hTTR fragment to form pathogenic protein aggregates implicates the serine protease i...

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Bibliographic Details
Main Authors: Daniele Peterle, Giulia Pontarollo, Stefano Spada, Paola Brun, Luana Palazzi, Alexej V. Sokolov, Barbara Spolaore, Patrizia Polverino de Laureto, Vadim B. Vasilyev, Ignazio Castagliuolo, Vincenzo De Filippis
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01493-0

Internet

https://doi.org/10.1038/s42003-020-01493-0

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