The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.

Protein phosphatase 2A (PP2A) is a ubiquitously expressed Serine-Threonine phosphatase mediating 30-50% of protein phosphatase activity. PP2A functions as a heterotrimeric complex, with the B subunits directing target specificity to regulate the activity of many key pathways that control cellular ph...

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Bibliographic Details
Main Authors: Mahnaz Janghorban, Ellen M Langer, Xiaoyan Wang, Derek Zachman, Colin J Daniel, Jody Hooper, William H Fleming, Anupriya Agarwal, Rosalie C Sears
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5708644?pdf=render

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http://europepmc.org/articles/PMC5708644?pdf=render

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