LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development

How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic a...

Full description

Bibliographic Details
Main Authors: Nicholas K. Vinckier, Nisha A. Patel, Ryan J. Geusz, Allen Wang, Jinzhao Wang, Ileana Matta, Austin R. Harrington, Matthew Wortham, Nichole Wetton, Jianxun Wang, Ulupi S. Jhala, Michael G. Rosenfeld, Christopher W. Benner, Hung-Ping Shih, Maike Sander
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16017-x

Internet

https://doi.org/10.1038/s41467-020-16017-x

Similar Items