Accurate quantification of circular RNAs identifies extensive circular isoform switching events

Quantification and characterization of circRNAs in sequencing data remains challenging, hindering efforts to understand their roles and regulation. The algorithm introduced here enables accurate circRNA quantification and permits insight into competitive splicing between linear and circular isoforms...

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Bibliographic Details
Main Authors: Jinyang Zhang, Shuai Chen, Jingwen Yang, Fangqing Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13840-9