Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease

Prion-Associated Neurodegeneration Causes Both Endoplasmic Reticulum Stress and Proteasome Impairment in a Murine Model of Spontaneous Disease

Prion diseases are a group of neurodegenerative disorders that can be spontaneous, familial or acquired by infection. The conversion of the prion protein PrP<sup>C</sup> to its abnormal and misfolded isoform PrP<sup>Sc</sup> is the main event in the pathogenesis of prion dise...

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Bibliographic Details
Main Authors: Alicia Otero, Marina Betancor, Hasier Eraña, Natalia Fernández Borges, José J. Lucas, Juan José Badiola, Joaquín Castilla, Rosa Bolea
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
ER stress
endoplasmic reticulum
UPS impairment
proteasome
prions
Online Access:https://www.mdpi.com/1422-0067/22/1/465

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https://www.mdpi.com/1422-0067/22/1/465

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