Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells

Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells

The proprotein convertase enzyme FURIN promotes the proteolytic maturation of pro-proteins and thereby it serves as an important factor for maintaining cellular homeostasis. In T cells, FURIN is critical for maintaining the T regulatory cell dependent peripheral immune tolerance and intact T helper...

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Bibliographic Details
Main Authors: Zsuzsanna Ortutay, Anna Grönholm, Melina Laitinen, Melinda Keresztes-Andrei, Ismail Hermelo, Marko Pesu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
Furin regulation
super-enhancer
interferon gamma
p300
proprotein convertase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.630389/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.630389/full

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