4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters

4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters

Abstract Background The alteration of lipid metabolism in cancer cells is recognized as one of the most important metabolic hallmarks of cancer. Membrane rafts defined as plasma membrane microdomains enriched in cholesterol and sphingolipids serve as platforms for signaling regulation in cancer. The...

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Bibliographic Details
Main Authors: Josiane Elia, Delphine Carbonnelle, Cédric Logé, Lucie Ory, Jean-Michel Huvelin, Mona Tannoury, Mona Diab-Assaf, Karina Petit, Hassan Nazih
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Lipids in Health and Disease
Subjects:
4-cholesten-3-one
Breast cancer cells
Lipogenesis
LXR
Cholesterol efflux
Membrane raft
Online Access:http://link.springer.com/article/10.1186/s12944-019-1103-7

Internet

http://link.springer.com/article/10.1186/s12944-019-1103-7

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