Cu/Zn-superoxide dismutase (GLY93→ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture

Cu/Zn-superoxide dismutase (GLY93→ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture

The cause of the selective degeneration of motor neurons in amyotrophic lateral sclerosis (ALS) remains a mystery. One potential pathogenic mechanism is excitotoxicity due to disturbances of glutamatergic neurotransmission, particularly via AMPA-sensitive glutamate receptors.We report here that moto...

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Bibliographic Details
Main Authors: Alida Spalloni, Federica Albo, Francesca Ferrari, Nicola Mercuri, Giorgio Bernardi, Cristina Zona, Patrizia Longone
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
ALS
Superoxide dismutase-1
Motor neuron
Excitotoxicity
Glutamate receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002493

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http://www.sciencedirect.com/science/article/pii/S0969996103002493

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