Recurrent gastrointestinal hemorrhage in treatment with dasatinib in a patient showing SMAD4 mutation with acute lymphoblastic leukemia Philadelphia positive and juvenile polyposis hereditary hemorrhagic telangiectasia syndrome

Recurrent gastrointestinal hemorrhage in treatment with dasatinib in a patient showing SMAD4 mutation with acute lymphoblastic leukemia Philadelphia positive and juvenile polyposis hereditary hemorrhagic telangiectasia syndrome

We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a <em>SMAD4</em> mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment...

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Bibliographic Details
Main Authors: Chiara Sartor, Cristina Papayannidis, Maria Chiara Abbenante, Ilaria Iacobucci, Alessandro Broccoli, Claudia Venturi, Nicoletta Testoni, Anna Ferrari, Giovanni Martinelli
Format: Article
Language:English
Published: PAGEPress Publications 2013-07-01
Series:Hematology Reports
Subjects:
juvenile poyposis, hereditary hemorrhagic telangiectasia, acute lymphoblastic leukemia, SMAD4, Philadelphia chromosome, dasatinib, hemorrhage
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/4800

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http://www.pagepress.org/journals/index.php/hr/article/view/4800

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