NFκB/Orai1 Facilitates Endoplasmic Reticulum Stress by Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease

NFκB/Orai1 Facilitates Endoplasmic Reticulum Stress by Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease

Non-esterified fatty acids (NEFAs) promote de novo lipogenesis, which caused abnormal hepatic lipid accumulation, by the NFκB–Orai1 pathway. Oxidative stress and endoplasmic reticulum (ER) stress have been recognized as key mechanisms in non-alcoholic fatty liver disease (NAFLD) pathogenesis. Whethe...

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Bibliographic Details
Main Authors: Bingbing Zhang, Ming Li, Ying Zou, Han Guo, Bingdong Zhang, Cheng Xia, Hongyou Zhang, Wei Yang, Chuang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
NAFLD
oxidative stress
ER stress
Orai1
NEFA
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00202/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00202/full

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