Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1

Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1

Intrauterine growth restriction (IUGR) and consumption of a high saturated fat diet (HFD) increase the risk of hypercholesterolemia, a leading cause of morbidity and mortality. The mechanism through which the cumulative impact of IUGR and in utero exposure to a maternal HFD increase cholesterol leve...

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Bibliographic Details
Main Authors: Erin K. Zinkhan, Baifeng Yu, Amnon Schlegel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
intrauterine growth restriction
high fat diet
microRNA-122
cholesterol
cholesterol 7α hydroxylase
perinatal environment
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00645/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00645/full

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