Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazones
Two new series of bis-thiazoles 6a-f and bis-thiazolones 9a-d were prepared via reacting bis-thiosemicarbazone 3 with hydrazonoyl chloride derivatives 4a-f and 7a-d, respectively, in dioxane under basic conditions. Another group of bis-thiazole derivatives 12a-h was prepared by reacting bis-thiosemi...
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doaj-21abe1081d0b455d8868d6944b9c57882021-09-11T04:28:34ZengElsevierArabian Journal of Chemistry1878-53522021-11-011411103396Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazonesRefaie M. Kassab0Sobhi M. Gomha1Sami A. Al-Hussain2Ahmed S. Abo Dena3Marwa M. Abdel-Aziz4Magdi E.A. Zaki5Zeinab A. Muhammad6Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, EgyptDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt; Department of Chemistry, Faculty of Science, Islamic University in AlmadinahAlmonawara, Almadinah Almonawara 42351, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia; Corresponding author.Departmentof Pharmaceutical Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt; Faculty of Oral and Dental Medicine, Future University in Egypt (FUE), New Cairo, EgyptRegional Center for Mycology and Biotechnology, Al-Azhar University, Cairo 11754, EgyptDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartmentof Pharmaceutical Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt; Corresponding author.Two new series of bis-thiazoles 6a-f and bis-thiazolones 9a-d were prepared via reacting bis-thiosemicarbazone 3 with hydrazonoyl chloride derivatives 4a-f and 7a-d, respectively, in dioxane under basic conditions. Another group of bis-thiazole derivatives 12a-h was prepared by reacting bis-thiosemicarbazone 3 with each of phenacyl bromide derivatives 10a-h under a similar reaction protocol. A plausible mechanism was proposed. Structural elucidation of the new products was established using both elemental and spectrometric/spectroscopic analyses. Structural, electronic, and the pharmacological characteristics of the prepared molecules were investigated with DFT calculations. Antibacterial and antifungal activities of the new bis-thiazoles were screened and compared with vancomycin and amphotericin B as antimicrobial standards. Molecular docking studies on the promising candidate compounds, with the lowest minimum inhibitory concentrations (MIC), were performed with SAP2 of C. albicans and FabI of S. aureus and P. aeruginosa.http://www.sciencedirect.com/science/article/pii/S1878535221004111CarbazoneHydrazonoyl chloridesBis-thiazolesAntimicrobialDFTIn-silico studies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Refaie M. Kassab Sobhi M. Gomha Sami A. Al-Hussain Ahmed S. Abo Dena Marwa M. Abdel-Aziz Magdi E.A. Zaki Zeinab A. Muhammad |
spellingShingle |
Refaie M. Kassab Sobhi M. Gomha Sami A. Al-Hussain Ahmed S. Abo Dena Marwa M. Abdel-Aziz Magdi E.A. Zaki Zeinab A. Muhammad Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazones Arabian Journal of Chemistry Carbazone Hydrazonoyl chlorides Bis-thiazoles Antimicrobial DFT In-silico studies |
author_facet |
Refaie M. Kassab Sobhi M. Gomha Sami A. Al-Hussain Ahmed S. Abo Dena Marwa M. Abdel-Aziz Magdi E.A. Zaki Zeinab A. Muhammad |
author_sort |
Refaie M. Kassab |
title |
Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazones |
title_short |
Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazones |
title_full |
Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazones |
title_fullStr |
Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazones |
title_full_unstemmed |
Synthesis and In-silico Simulation of Some New Bis-thiazole Derivatives and Their Preliminary Antimicrobial Profile: Investigation of Hydrazonoyl Chloride Addition to Hydroxy-Functionalized Bis-carbazones |
title_sort |
synthesis and in-silico simulation of some new bis-thiazole derivatives and their preliminary antimicrobial profile: investigation of hydrazonoyl chloride addition to hydroxy-functionalized bis-carbazones |
publisher |
Elsevier |
series |
Arabian Journal of Chemistry |
issn |
1878-5352 |
publishDate |
2021-11-01 |
description |
Two new series of bis-thiazoles 6a-f and bis-thiazolones 9a-d were prepared via reacting bis-thiosemicarbazone 3 with hydrazonoyl chloride derivatives 4a-f and 7a-d, respectively, in dioxane under basic conditions. Another group of bis-thiazole derivatives 12a-h was prepared by reacting bis-thiosemicarbazone 3 with each of phenacyl bromide derivatives 10a-h under a similar reaction protocol. A plausible mechanism was proposed. Structural elucidation of the new products was established using both elemental and spectrometric/spectroscopic analyses. Structural, electronic, and the pharmacological characteristics of the prepared molecules were investigated with DFT calculations. Antibacterial and antifungal activities of the new bis-thiazoles were screened and compared with vancomycin and amphotericin B as antimicrobial standards. Molecular docking studies on the promising candidate compounds, with the lowest minimum inhibitory concentrations (MIC), were performed with SAP2 of C. albicans and FabI of S. aureus and P. aeruginosa. |
topic |
Carbazone Hydrazonoyl chlorides Bis-thiazoles Antimicrobial DFT In-silico studies |
url |
http://www.sciencedirect.com/science/article/pii/S1878535221004111 |
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