Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations

Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations

Summary: Colorectal cancer (CRC) is one of the most common cancers worldwide, in which adenomatous polyposis coli (APC) mutations are frequently and uniquely observed. Here we find that cis-HOX (circular RNA stabilizing HOXC10) is robustly expressed in colorectal tumor-initiating cells (TICs). cis-H...

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Bibliographic Details
Main Authors: Zhenzhen Chen, Jiayi Wu, Benyu Liu, Guangtan Zhang, Zhiwei Wang, Lulu Zhang, Kaili Wang, Zusen Fan, Pingping Zhu
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
colorectal cancer
tumor initiating cells
self-renewal
metastasis
cis-HOX
HOXC10
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721008482

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http://www.sciencedirect.com/science/article/pii/S2211124721008482

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