The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

BACKGROUND: Four and a half LIM-only protein 2 (FHL2) has been implicated in multiple signaling pathways that regulate cell growth and tissue homeostasis. We reported previously that FHL2 regulates cyclin D1 expression and that immortalized FHL2-null mouse embryo fibroblasts (MEFs) display reduced l...

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Bibliographic Details
Main Authors: Charlotte Labalette, Yann Nouët, Florence Levillayer, Carolina Armengol, Claire-Angélique Renard, Guillaume Soubigou, Tian Xia, Marie-Annick Buendia, Yu Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2583050?pdf=render

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http://europepmc.org/articles/PMC2583050?pdf=render

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