Role of Alternative Lipid Excipients in the Design of Self-Nanoemulsifying Formulations for Fenofibrate: Characterization, in vitro Dispersion, Digestion and ex vivo Gut Permeation Studies

Role of Alternative Lipid Excipients in the Design of Self-Nanoemulsifying Formulations for Fenofibrate: Characterization, in vitro Dispersion, Digestion and ex vivo Gut Permeation Studies

Background: The choice of lipid excipients and their origin are crucial determinant factors in the design of self-nanoemulsifying drug delivery system (SNEDDS).Aim: To investigate the aspects of alternative excipients which can influence the development of efficient SNEDDS and determine the fate of...

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Bibliographic Details
Main Authors: Aws Alshamsan, Mohsin Kazi, Mohamed M. Badran, Fars Kaed Alanazi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
lipid-based formulation
self-nanoemulsifying drug delivery systems (SNEDDS)
in vitro dynamic dispersion
in vitro digestion
fenofibrate
solubility improvement
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01219/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01219/full

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