Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

Excitotoxicity plays a key role in the selective vulnerability of striatal neurons in Huntington disease (HD). Decreased glutamate uptake by glial cells could account for the excess glutamate at the synapse in patients as well as animal models of HD. The major molecule responsible for clearing gluta...

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Bibliographic Details
Main Authors: Kun Huang, Martin H. Kang, Caitlin Askew, Rujun Kang, Shaun S. Sanders, Junmei Wan, Nicholas G. Davis, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
Palmitoylation
Glial glutamate transporter
GLT-1
Excitotoxicity
YAC128
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001890

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http://www.sciencedirect.com/science/article/pii/S0969996110001890

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