Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia

Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia

Cilia are evolutionarily highly conserved organelles with important functions in many organs. The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 conformation in primary cilia or 9 + 2 in motile cili...

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Bibliographic Details
Main Authors: Paweł K. Łysyganicz, Niedharsan Pooranachandran, Xinming Liu, Kathryn I. Adamson, Katarzyna Zielonka, Stone Elworthy, Fredericus J. van Eeden, Andrew J. Grierson, Jarema J. Malicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hdac6
Sirt2
deacetylation
cilia
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.676214/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.676214/full

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