Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

Tuberculosis (TB) is the leading cause of death by an infectious agent, and developing an effective vaccine is an important component of the WHO's EndTB Strategy. Non-human primate (NHP) models of vaccination are crucial to TB vaccine development and have informed design of subsequent human tri...

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Bibliographic Details
Main Authors: Louis R. Joslyn, Elsje Pienaar, Robert M. DiFazio, Sara Suliman, Benjamin M. Kagina, JoAnne L. Flynn, Thomas J. Scriba, Jennifer J. Linderman, Denise E. Kirschner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
tuberculosis
non-human primate
H56
mathematical modeling
bacillus calmette–guerin (BCG)
vaccination
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01734/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01734/full

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