Decreased nuclear Pten in neural stem cells contributes to deficits in neuronal maturation

Decreased nuclear Pten in neural stem cells contributes to deficits in neuronal maturation

Abstract Background PTEN, a syndromic autism spectrum disorder (ASD) risk gene, is mutated in approximately 10% of macrocephalic ASD cases. Despite the described genetic association between PTEN and ASD and ensuing studies, we continue to have a limited understanding of how PTEN disruption drives AS...

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Bibliographic Details
Main Authors: Shin Chung Kang, Ritika Jaini, Masahiro Hitomi, Hyunpil Lee, Nick Sarn, Stetson Thacker, Charis Eng
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Autism
Subjects:
PTEN mutation
Neural stem cells
Autism spectrum disorder
Neural development
Neuronal maturation
Creb activation
Online Access:http://link.springer.com/article/10.1186/s13229-020-00337-2

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