MicroRNA-506 inhibits tumor growth and metastasis in nasopharyngeal carcinoma through the inactivation of the Wnt/β-catenin signaling pathway by down-regulating LHX2

MicroRNA-506 inhibits tumor growth and metastasis in nasopharyngeal carcinoma through the inactivation of the Wnt/β-catenin signaling pathway by down-regulating LHX2

Abstract Background Epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis with the involvement of microRNAs (miRNAs). This study aims to assess the role of miR-506 working in tandem with LIM Homeobox 2 (LHX2) in EMT and metastasis through the...

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Bibliographic Details
Main Authors: Tian-Song Liang, Ying-Juan Zheng, Juan Wang, Jing-Yi Zhao, Dao-Ke Yang, Zhang-Suo Liu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
MicroRNA-506
LIM Homeobox 2
Wnt/β-catenin signaling pathway
Epithelial-mesenchymal transition
Lymph node metastasis
Nasopharyngeal carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-019-1023-4

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http://link.springer.com/article/10.1186/s13046-019-1023-4

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