LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice developed highly penetrant T-ALL by two distinct...

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Bibliographic Details
Main Authors: Stephen Smith, Rati Tripathi, Charnise Goodings, Susan Cleveland, Elizabeth Mathias, J Andrew Hardaway, Natalina Elliott, Yajun Yi, Xi Chen, James Downing, Charles Mullighan, Deborah A Swing, Lino Tessarollo, Liqi Li, Paul Love, Nancy A Jenkins, Neal G Copeland, Mary Ann Thompson, Yang Du, Utpal P Davé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897537?pdf=render

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http://europepmc.org/articles/PMC3897537?pdf=render

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