Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.
Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that neural activity-regulated negative factors produced by muscle drive neurodegen...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-03-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC6417855?pdf=render |