A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

Cell-type-specific functions and identity are tightly regulated by interactions between the cell cytoskeleton and the extracellular matrix (ECM). Human pluripotent stem cells (hPSCs) have ultimate differentiation capacity and exceptionally low-strength ECM contact, yet the organization and function...

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Bibliographic Details
Main Authors: Elisa Närvä, Aki Stubb, Camilo Guzmán, Matias Blomqvist, Diego Balboa, Martina Lerche, Markku Saari, Timo Otonkoski, Johanna Ivaska
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
human pluripotent stem cell
focal adhesion
actin cytoskeleton
total internal reflection fluorescence microscopy
traction force microscopy
Rho-ROCK-myosin signaling
integrin activity
pluripotency
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111730228X

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http://www.sciencedirect.com/science/article/pii/S221367111730228X

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