FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration.

FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration.

Cell migration involves a multitude of signals that converge on cytoskeletal reorganization, essential for development, immune responses and tissue repair. Using knockdown and dominant negative approaches, we show that the microtubule-associated Ste20-like kinase SLK is required for focal adhesion t...

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Bibliographic Details
Main Authors: Simona Wagner, Chris J Storbeck, Kristin Roovers, Ziad Y Chaar, Piotr Kolodziej, Marlene McKay, Luc A Sabourin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2270904?pdf=render

Internet

http://europepmc.org/articles/PMC2270904?pdf=render

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