SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Cells deficient in SPRTN protease activity exhibit severe DNA-protein crosslink induced replication stress and genome instability. Here the author reveal a functional link between the SPRTN protease and the CHK1 kinase during physiological DNA replication.

Bibliographic Details
Main Authors: Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter, Marta Popović, John Fielden, Bruno Vaz, Judith Oehler, Domenic Pilger, Davor Lessel, Katherine Wiseman, Abhay Narayan Singh, Iolanda Vendrell, Roman Fischer, Melanie Philipp, Kristijan Ramadan
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11095-y

Internet

https://doi.org/10.1038/s41467-019-11095-y

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